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Amlodipine Besylate (CAS No 111470-99-6),  is a long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION.

Amlodipine Besylate is the besylate salt of amlodipine, a synthetic dihydropyridine with antihypertensive and antianginal effects. Amlodipine inhibits the influx of extracellular calcium ions into myocardial and peripheral vascular smooth muscle cells, thereby preventing vascular and myocardial contraction. This results in a dilatation of the main coronary and systemic arteries, decreased myocardial contractility, increased blood flow and oxygen delivery to the myocardial tissue, and decreased total peripheral resistance. This agent may also modulate multi-drug response (MDR) activity through inhibition of the p-glycoprotein efflux pump.

Specification

Appearance                    white or almost white powder 

Identification                  Infrared spectrum complies with EPRS

Water, %                        ≤0.50

Residue on Ignition, %    ≤0.20

Optical rotation               -0.10^o~+0.10^o

Heavy metals, %            ≤0.002

Related substance, %  

   Impurity D:                 ≤0.30

   Impurity A:                 ≤0.15

   Impurity E:                 ≤0.15

   Any single impurity:     ≤0.10

   Total impurities:          ≤0.80

Residual solvent, ppm     ≤2000 (Ethanol)

Assay, %                        97.0~102.0 

Application
Amlodipine Besylate is a common drug in our country at present the treatment of hypertension and angina, which belongs to the calcium channel blocker, into the cells of myocardium and vascular smooth muscle by blocking calcium ions across the membrane, vascular smooth muscle relaxation directly to antihypertensive effect, clinical medication alone or with other antihypertensive drugs in the treatment of primary hypertension. 

Packaging&Storage

25 kg/drum.

Stored in dry and ventilation place, far from heat and water.